IBBEA   24401
INSTITUTO DE BIODIVERSIDAD Y BIOLOGIA EXPERIMENTAL Y APLICADA
Unidad Ejecutora - UE
artículos
Título:
In vitro Interference of a Glyphosate Commercial Formulation with the Stimulation of Ovarian Maturation by Progesterone, in the Estuarine Crab Neohelice granulata
Autor/es:
LONNÉ, NOELIA; CANOSA, IVANA SOFÍA; MEDESANI, DANIEL ALBERTO; SILVEYRA, GABRIELA ROMINA; RODRÍGUEZ, ENRIQUE MARCELO
Revista:
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
Editorial:
SPRINGER
Referencias:
Lugar: Berlin; Año: 2021 vol. 106 p. 583 - 588
ISSN:
0007-4861
Resumen:
The addition of Roundup Ultramax® (0.2 mg/L of glyphosate in the incubation medium)was able to potentiate the stimulating effect of progesterone on total vitellogenic protein(Vg) content of ovarian pieces from crabs. Moreover, the sole addition of mifepritone(antagonist of progesterone receptors) was able to produce a decrement of the Vgcontent, which was not reverted by the addition of Roundup. A similar result wasconfirmed by a third assay by means of a histological analysis, which showed thatmifepristone, both alone and in combination with Roundup, inhibited the ovarianmaturation, while Roundup alone increased it, in terms of a higher proportion ofvitellogenic oocytes. We conclude that Roundup could stimulate the progesteronesecretion exerted by the ovary and/or could act as a partial agonist of the progestorereceptor in the same tissue.