Tolerance and sensitization induced by ethanol in preweanling rats: effects of the administration of a sequestering agent of acetaldehyde

MOLINA, J.C.; CASTELLÓ, STEFANÍA; ARIAS, C.

Mar del Plata

Congreso; XXXII Congreso Anual de la Sociedad Argentina de Neurociencias; 2017

Preweanlingrats consistently display a locomotor stimulating effect in responseto medium-to-high ethanol doses, and we have recently reported thatchronic ethanol exposure during the second postnatal week results intolerance or sensitization to this effect of the drug. The locomotorstimulating effect of ethanol and sensitization of this effect hasnot been frequently reported in adult rats. One possible explanationto this ontogenetic difference in the sensitivity to ethanol is thedifference in central and peripheral ethanol metabolism observed ateach age. Our goal was to explore the effect of the administration ofd-penicillamine (dp), a sequestering agent of acetaldehyde, over thestimulating effect of ethanol after acute or chronic exposure to thedrug in two-week-old rats. Firstly, we administrated rats (PD 12)with 2.5 g/kg ethanol, 25 min after being treated with saline or dp(50 or 75 mg/kg). Both dp doses reduced the acute stimulating effectof ethanol. Then we evaluated whether dp administration at trainingreduced tolerance and sensitization. Our results revealed that dp didnot block these ethanol effects. These data suggests thatacetaldehyde metabolism is involved in the acute locomotor responseof ethanol, but not in the development of tolerance and sensitizationin infant rats.p { margin-bottom: 0.25cm; line-height: 120%; }