CIECS   20730
CENTRO DE INVESTIGACIONES Y ESTUDIOS SOBRE CULTURA Y SOCIEDAD
Unidad Ejecutora - UE
artículos
Título:
A comparison of behavioral and pharmacological interventions to attenuate reactivated fear memories
Autor/es:
MUGNAINI, MATÍAS; URCELAY, GONZALO P.; ALFEI, JOAQUÍN M.; BECKERS, TOM; ALFEI, JOAQUÍN M.; BECKERS, TOM; MONTI, ROQUE I. FERRER; BUENO, ADRIÁN M.; MONTI, ROQUE I. FERRER; MOLINA, VICTOR A.; BUENO, ADRIÁN M.; MOLINA, VICTOR A.; MUGNAINI, MATÍAS; URCELAY, GONZALO P.
Revista:
LEARNING & MEMORY (COLD SPRING HARBOR, N.Y.)
Editorial:
COLD SPRING HARBOR LAB PRESS
Referencias:
Año: 2017 vol. 24 p. 369 - 374
ISSN:
1072-0502
Resumen:
Two experiments using rats in a contextual fear memory preparation compared two approaches to reduce conditioned fear: (1) pharmacological reconsolidation blockade and (2) reactivation-plus-extinction training. In Experiment 1, we explored different combinations of reactivation-plus-extinction parameters to reduce conditioned fear and attenuate reacquisition. In Experiment 2, memory reactivation was followed by extinction training or administration of midazolam (MDZ) (vs. vehicle) to reduce conditioned fear and attenuate spontaneous recovery. We found both treatments to be equally effective in both experiments. This study suggests that parameters leading to memory destabilization during reactivation are critical to observe long-lasting effects of MDZ or reactivation plus extinction.