Natural Hydroxyapatite Bioceramic-Collagen based Bone Composites Production.

C.FERNADEZ; A. OZOLS; C. MARTINEZ ; J. FAIG; J. LOCS; L. CIMDIņA-BēRZIņA

Chengdu

Congreso; 9th World Biomaterials Congress; 2012

Biomaterial Society

The collagen and calcium phosphate based composites were synthesized with the aim to use them as bone substitutes. This combination pretends to mimics the synergy of organic and inorganic phases during bone genesis. The effort was focused in getting stiff composites, able to be moulded in as dowels and plates that fit into alveolar defects and allow lifting sinus ridge, situation barely satisfied by known commercial products. The organic phase is mainly composed by collagen, extracted from bovine ligaments and bones, by chemical digestion in bioreactor. The inorganic phase was composed by ceramic particles obtained from chemically and thermally reprocessed fresh bovine bone. The product was frizzed, dried in mild vacuum, and sterilizing under per-acetic acid vapour. The mechanical performance is evaluated thought flexural strength. Such strength could be attributed to the composite microstructure of ceramic particles tapped and adhered to organic matrix, as it is observed by electronic microscope. The process was able to manage by means of phase ratio the porosity in the 50-90 % range. These features make easer the use of composites as bone fillers, with strength higher than similar known composites. The moulding ability of these composites is adequate for producing clinically useful pieces, which good mechanical performance