MODIFICATIONS IN NANOPARTICLE-SIZE DISTRIBUTION DUE TO CENTRIFUGATION CLEANING REPETITIONS

MELE, NICOLÁS G.; SÁNCHEZ, FRANCISCO H.; MENDOZA ZÉLIS, PEDRO; ARRIETA GAMARRA, DIANA I.; PASQUEVICH, GUSTAVO A.

Brasov

Conferencia; International Conference on the Applications of the Mössbauer Effect; 2021

National Institute of Materials Physics ? Romania

The repeatability of the magnetic nanoparticles synthesis process and the dependence of theircharacteristics on the synthesis parameters are fundamental to ensure a systematic study,especially when multiple batches are needed. This repeatability is very important for differentapplications, in particular for the biomedical ones [1]. It is essential to avoid adding extravariability into biological systems that are already highly variable. This concern is promptinga standardization of the processes of synthesis and characterization of magnetic nanoparticles[2,3]. The properties of magnetic nanoparticles are strongly dependent on the synthesisprocess. Cleaning step is an essential part of the final synthesis processes. Moreover, washingby centrifugation can be used to modify the particle size distribution. In this work we showthe effect of adding an extra spin cleaning step on the particle size distribution.We synthesized iron oxide nanoparticles by coprecipitation of Fe salts. The particles werestabilized with citric acid [4] and washed, discarding centrifugation supernatants in thepresence of acetone. The product was characterized by XRD, TEM, VSM and Mössbauereffect spectroscopy at room temperature. A 10% increase in the average particle diameter wasdetermined from the analysis of the Mössbauer spectra, after adding an extra cleanup step tothe synthesis protocol.