Synthesis of highly stable Fe/FeOx@citrate colloids with strong magnetic response by mechanochemistry and coprecipitation for biomedical and environmental applications

CORAL, D.F.; MUÑOZ MEDINA, G.A.; MURACA, D.; FERNÁNDEZ VAN RAAP, M.B.; SÁNCHEZ, F.H.

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2020 vol. 508 p. 166759 - 166769

0304-8853

We present a simple, scalable, and low-cost route for producing aqueous colloids of nanometer size Fe corescoated with iron oxide and stabilized with sodium citrate. The Fe cores were obtained by mechanosynthesis bymeans of a highly exothermic solid-state reaction between FeCl3 and Mg, in a dispersive inert NaCl medium. Theoptimal experimental conditions for achieving a full reaction were determined with a Retsch 2000 oscillatorymill. Then the production yield was successfully 16-fold scaled using a rotatory Fritsch Pulverissete 7 mill. Toprovide biocompatibility and facilitate colloid stabilization, the Fe cores were coated with a Fe-oxide shellproduced by chemical coprecipitation, and finally, the system Fe/FeOx was functionalized with sodium citrate inwater. The so-obtained Fe/FeOx@Cit (4/3 < x < 3/2) nanoparticles have a mean size of about 11?12 nm,specific saturation magnetization around 130 Am2/kgFe and ζ -potential of −40 mV. The time dependence of thereaction progress could be described by a simple function of the mass ratio of milling balls to processed materialand time. The resultant colloids are excellent candidates for biomedical and environmental remediation applications.