IFLP   13074
INSTITUTO DE FISICA LA PLATA
Unidad Ejecutora - UE
artículos
Título:
Aromatic amine N-oxide metal complexes: searching for prospective agents against infectious diseases
Autor/es:
E. RODRÍGUEZ ARCE; M. F. MOSQUILLO; L. PÉREZ-DÍAZ; G. A. ECHEVERRÍA; O. E. PIRO; A. MERLINO; L. COITIÑO; C. MARÍNGOLO RIBEIRO; C. Q. F. LEITE; F. R. PAVAN; L. OTERO; D. GAMBINO
Revista:
JOURNAL OF THE CHEMICAL SOCIETY, DALTON TRANSACTIONS
Editorial:
RCS Publishing
Referencias:
Lugar: Londres; Año: 2015 vol. 44 p. 14453 - 14464
ISSN:
0300-9246
Resumen:
Searching for prospective agents against infectious diseases,1,1´-bis (dipheny1phosphino)ferrocene pyridine-2-thiolato-1-oxide M(II) hexafluorophosphate compounds[M(mpo)(dppf)](PF6), where M(II) = palladium or platinum,were synthesized and fully characterized in the solid state and in solutionusing experimental and DFT computational techniques.The compounds are isomorphous and the M(II) transition metal ions are in a nearly planar trapezoidal cis-coordination bound to thepyridine-2-thiolato-1-oxide(mpo) and to the 1,1´-bis (dipheny1phosphino)ferrocene molecules, both acting as bidentateligands.Both compounds showed high cytotoxic activity on Trypanosomacruzi and Mycobacterium tuberculosis(MTB) and acceptable selectivities towards MTB, but good to excellent selectivity index values as anti-T.cruzicompounds. The inclusion of the ferrocene moiety (dppfligand) improved the selectivity towards the parasite when compared to the previously reported [M(mpo)2] complexes. Related to the probable mechanism of action of the complexes, molecular docking studies on modeled T. cruzi NADH-fumaratereductase predicted that both should be very good inhibitors of the enzyme. According to allobtained results, both [M(mpo)(dppf)](PF6) compounds could be considered prospective anti-trypanosomalagents that deserve further research.