Complexation of 2-acetylpyridine- and 2-benzoylpyridine-derived hydrazones to copper(II) as an effective strategy for antimicrobial activity improvement

A. A. RECIO DESPAIGNE; F. B. DA COSTA; O. E. PIRO; E. E. CASTELLANO; S. R. W. LOURO ; H. BERALDO

POLYHEDRON

PERGAMON-ELSEVIER SCIENCE LTD

Año: 2012 vol. 38 p. 285 - 290

0277-5387

Complexes [Cu(2AcPh)Cl]2H2O (1), [Cu(2AcpClPh)Cl]2H2O (2), [Cu(2AcpNO2Ph)Cl] (3), [Cu(2BzPh)Cl] (4). [Cu(2BzpClPh)Cl] (5) and [Cu(2BzpNO2Ph)Cl] (6) were obtained with 2-acetylpyridine-phenylhydrazone (H2AcPh), 2-acetylpyridine-para-chloro-phenylhydrazone (H2AcpClPh), 2-acetylpyridine-para-nitro-phen-ylhydrazone (H2AcpNO2Ph), 2-benzoylpyridine-phenylhydrazone (H2BzPh), 2-benzoylpyridine-para-chloro-phenylhydrazone (H2BzpClPh) and 2-benzoylpyridine-para-nitro-phenylhydrazone (H2BzpNO2Ph). The hydrazones showed poor antibacterial effect against Staphylococcus aureus, Enterococcus faecalis and Pseudomonas aeruginosa but demonstrated significant antifungal activity againstCandida albicans.Uponcoor-dination to copper(II) the antibacterial and antifungal activities appreciably increased. H2AcpClPh, H2BzpClPh and their copper(II) complexes (2) and (5), respectively, were as active as fluconazole against C. albicans.