IFLP   13074
INSTITUTO DE FISICA LA PLATA
Unidad Ejecutora - UE
artículos
Título:
Analgesic and anti-inflammatory activities of acylhydrazone H2LASSBio-466, its regioisomer H2LASSBio-1064, and their zinc(II) complexes
Autor/es:
W. BISPO JÚNIOR; M. S. ALEXANDRE-MOREIRA; M. A. ALVES; A. PEREZ-REBOLLEDO; G. L. PARRILHA; E. E. CASTELLANO; O. E. PIRO; E. J. BARREIRO; L. MOREIRA LIMA; H. BERALDO
Revista:
MOLECULES
Editorial:
MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL-MDPI
Referencias:
Lugar: Basel; Año: 2011 vol. 16 p. 6902 - 6915
ISSN:
1420-3049
Resumen:
Salicylaldehyde 2-chlorobenzoyl hydrazone(H2LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H2LASSBio-1064) and their complexes [Zn(LASSBio-466)H2O]2 (1) and [Zn(HLASSBio-1064)Cl]2 (2) were evaluated in animal models of peripheral and central nociception, and acute inflammation. All studied compounds significantly inhibited acetic acid-induced writhing response. Upon coordination the anti-nociceptive activity was favored in the complex1. H2LASSBio-466 inhibited only the first phase of the formalin test, while1was active in the second phase, like indomethacin, indicating its ability to inhibit nociception associated with the inflammatory response. Hence coordination to zinc(II) altered thepharmacological profile of H2LASSBio-466.H2LASSBio-1064 inhibited both phases but this effect was not improved by coordination. The studied compounds did not increase the latency of response in the hot plate model, indicating their lack of central anti-nociceptive activity. All compounds showed levels of inhibition of zymosan-induced peritonitis comparable or superior to indomethacin, indicating an expressive anti-inflammatory profile.