Dalea extracts as potential ingredients for phyto- formulations: antioxidant, antityrosinase, antifungal properties and in vitro cytotoxicity evaluations

SANTI, DANIELA; ORTEGA, MARÍA GABRIELA; PERALTA, MARIANA A.; DEL GAUDIO, MICAELA; CABRERA, JOSÉ LUIS

Belo Horizonte

Congreso; I Congress on Science, Biodiversity and Sustainability; 2019

Núcleo de Productos Naturales Bioactivos y sus Aplicaciones. AUGM

The American Dalea L. genus (Fabaceae) has its habitat from the southwesternUnited States to central Argentina and Chile. According to ethnobotanical andethnomedical reports, several Dalea species are applied in gastrointestinal anddermatological illness and used for their antiinflammatory and analgesic properties.Phytochemical studies have disclosed the presence of prenylflavonoids in Dalea genus.Their bioactivities include antioxidant, antityrosinase, antimicrobial properties, between others. Continuing with the research in Dalea genus, here we present the phytochemical and biological activities analysis of three South American Dalea species: D. leporina, D.boliviana and D. pazensis.The hydroalcoholic extracts from roots of these species were obtained and theirantioxidant, antityrosinase, antifungal and cytotoxicity activities were determined and compared among themselves and with respect to reference compounds. Furthermore, the chemical profile was investigated focused in the presence of 8PP [2?,4?-dihydroxy-5?-(1???,1???-dimethylallyl)-8 prenylpinocembrin] the prenylflavonoid with the most biological studies in this genus. From these studies, the polar extracts of the three Dalea species exerted relevant biological activities and low cytotoxicity in vitro. Moreover, the flavonoid 8PP was present in all of them. These results allow us to propose the potential use of these natural products as phyto-bioactive ingredients in several industries such as food, pharmaceutical, or cosmetic. Further studies in vivo are necessary to guarantee the security of these extracts for human use.