Dendronized nanotubes for protein alignment

WOLFEL, ALEXIS; MONTENEGRO, JAVIER; GRANJA, JUAN; ROJO, JAVIER

Santiago de Compostela

Encuentro; IV Encuentro sobre Dendrímeros EDEN 4; 2014

Cyclic peptides (CPs) with an even number of amino acids (Aa) of alternating chirality have the ability to self-assemble into nanotubes by the formation of beta sheet type hydrogen bonded networks. The first advantage of this tubular structures, cylindrical materials with a inner hole, is the possibility of precisely tuning up their diameter and modify the external surface using different number and type of amino acids in the sequences of the CPs. The construction of this nanometric structures is important due to the different possible applications such as the design of new synthetic ionic channels, the preparation of antimicrobial reagents with novel action mechanisms and/or in the development of photovoltaic materials, etc. We introduced herein the alignment of sugar moieties (D-manose) using self-assembled cyclic peptide nanotubes for the immobilization and alignment of lectine type proteins through multivalent interactions. We plan to prepare a cyclopeptide that will be modified with a glycosidic dendron through click-chemistry. Then, the self-assembly of the prepared dendronized CPs into nanotubes were studied. Finally we will evaluate their interaction with the natural receptors of the saccharides (lectines) looking to the influence of the supramolecular linear interactions and their effect on multivalent recognition.