IMBIV   05474
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA VEGETAL
Unidad Ejecutora - UE
artículos
Título:
Melanogenic inhibitory effects of Triangularin in B16F0 melanoma cells, in vitro and molecular docking studies
Autor/es:
?MARCELO PUIATTI; MARÍA D. SANTI; JOSÉ LUIS CABRERA; ?MARIANA A PERALTA; MARIANA G. ORTEGA
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY.
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2019 p. 3722 - 3728
ISSN:
0968-0896
Resumen:
The lack of secure therapies for hyperpigmentation disorders, without serious adverse effects, and the latestreports relating melanogenic disorders with development of neurodegenerative diseases, encourage the continuingsearch for new drugs for the treatment of such disorders. In this sense, the plant kingdom is an importantsource of bioactive natural products with great potential for the research and development of new therapeutics.The present study evaluated the anti-melanogenic activity of the natural methoxylated chalcone, 2′,6′-dihydroxy-4′-methoxy-3′-methylchalcone (Triangularin, T), on diphenolase activity from mushroom tyrosinase andon murine B16F0 melanoma cell model. In addition, molecular modelling studies were carried out in order tounderstand the inhibitory activity observed. T showed a potent anti-melanogenic activity being more active thankojic acid (KA) on tyrosinase isolated of both sources and on intracellular tyrosinase. Molecular docking studiesdisplayed important interactions between T and the active site of tyrosinase. Our results suggest that T may beuseful for the treatment of hyperpigmentary disorders.