IMBIV 05474
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA VEGETAL
Unidad Ejecutora - UE
artículos
Título:
Selective Antiproliferative Withanolides from Species in the GeneraEriolarynx and Deprea
Autor/es:
JOSÉ M. PADRÓN; CARINA N. CASERO; SEBASTIÁN J. CASTRO; VIVIANA E. NICOTRA
Revista:
JOURNAL OF NATURAL PRODUCTS
Editorial:
AMER CHEMICAL SOC
Referencias:
Lugar: Washington; Año: 2019 vol. 82 p. 1338 - 1344
ISSN:
0163-3864
Resumen:
Four new withanolides (2−5), together with 4β,7β,20-trihydroxy-1-oxowitha-2,5,24-trienolide (1), were isolated from the aerial parts of Eriolarynxiochromoides. The antiproliferative activity of all compounds purified from E.iochromoides together with four withaphysalins and four physangulidines isolatedpreviously from three Deprea species were evaluated against human solid tumor celllines. Four withanolides showed antiproliferative activity comparable in potency to cisplatin. Selectivity toward cancer cells and interaction with P-glycoprotein of the active withanolides were evaluated.
