IMBIV 05474
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA VEGETAL
Unidad Ejecutora - UE
artículos
Título:
Quercetin Tetraacetyl Derivative Inhibits Lps- Induced Nitric Oxide Synthase (iNOS) Expression In J774A.1 Cells
Autor/es:
ORTEGA MARÍA GABRIELA; SARAGUSTI ALEJANDRA; JOSÉ LUIS CABRERA; GUSTAVO CHIABRANDO
Revista:
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
Editorial:
ELSEVIER SCIENCE INC
Referencias:
Año: 2010 vol. 498 p. 105 - 110
ISSN:
0003-9861
Resumen:
cells. Our results demonstrate that only TAQt inhibited the NO production by decreasing the iNOS mRNA and protein levels. In addition, we showed that TAQt blocked the LPS-induced nuclear NF-êB translocation by inhibiting the IêBá degradation. Hence, as TAQt inhibited the LPS-induced iNOS expression and NO production, it could therefore be considered as a potential therapeutic agent for the treatment of inflammatory diseases related with the NO system.
