IMBIV 05474
INSTITUTO MULTIDISCIPLINARIO DE BIOLOGIA VEGETAL
Unidad Ejecutora - UE
artículos
Título:
N-demethyl-sauroxine, a novel Lycodine Group alkaloid from Huperzia saururus
Autor/es:
MARIANA G. VALLEJO; MARIA GABRIELA ORTEGA; JOSE; L. CABRERA ; ALICIA MARIEL AGNESE
Revista:
TETRAHEDRON LETTERS
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2013 vol. 54 p. 5197 - 5200
ISSN:
0040-4039
Resumen:
The present study describes the isolation and identification of N-demethyl-sauroxine, a novel Lycopodium alkaloid obtained from Huperzia saururus (Lam.) Trevis. (Lycopodiaceae). Its structure and relative stereochemistry were elucidated on the basis of its spectral data and chemical correlations. Additionally, acetylcholinesterase inhibitory activity was evaluated (IC50 = 209.6 ± 1.1 lM). The structure of the already identified alkaloid sauroxine was also re-validated through two dimensional NMR data
