Thermosensitive nanogels based on dendritic polyglicerol and N-isopropylacrylamide for biomedical applications.

JULIO CUGGINO; CECILIA ALVAREZ I.; MIRIAM STRUMIA; PIA WELKER; KAI LICHA; DIRK STEINHILBER; RADU CRISTIAN MUTHIHAC; MARCELO CALDERÓN

SOFT MATTER

ROYAL SOC CHEMISTRY

Año: 2011 vol. 7 p. 11259 - 11266

1744-683X

In this paper we describe a methodology for the synthesis of thermoresponsive polyglycerol-based nanogels through precipitation polymerization. A systematic analysis of the preparative conditions and composition regarding the nanogel size is presented. The thermoresponsive properties of the synthesized nanogels, as well as the cytotoxicity and uptake in three different cell lines were investigated. The thermoresponsive behavior, the enhanced biocompatible profile, and the cell penetrating properties of the nanogels highlight the potential of such constructs for application as smart, environmentally-responsive materials.