INVESTIGADORES
PARUSSINI GIMENEZ silvana fabiola
congresos y reuniones científicas
Título:
NEW ROLES FOR PROTEASES IN THE INFECTION BIOLOGY OF COCCIDIAN PARASITES
Autor/es:
FABIOLA PARUSSINI; CHIN FEN TEO; JILL HARPER; EMILY BINDER; KAMI KIM; VERN B. CARRUTHERS
Lugar:
Foz do Iguassu, Paraná
Reunión:
Conferencia; The IXth International Coccidiosis Conference; 2005
Institución organizadora:
Fundação APINCO de Ciência e Tecnologia Avícolas
Resumen:
Coccidian parasites including
Toxoplasma gondii cause widespread infections and
disease in humans and animals. The need for new therapeutic
agents along with the fascinating biology of these
parasites has fueled a keen interest in understanding
how key steps in the life cycle are regulated. Proteolysis
is intimately associated with cell and tissue invasion
by these obligate intracellular parasites and recent
studies have begun to identify the proteases involved
in these processes. Based on clues from inhibitor
experiments and cleave site mapping studies, we and
others are using emerging genome information and molecular
genetics to identify and validate proteases that regulate
secretory organelle biogenesis and invasion protein
activity. These studies are revealing roles for a
variety of proteases including cathepsins, subtilases,
and rhomboids in cell and tissue invasion. The identification
of highly selective inhibitors for these proteases
has the potential to not only further dissect their
role in infection but also to potentially prevent
or ameliorate disease.