INVESTIGADORES
MENZELLA Hugo Gabriel
congresos y reuniones científicas
Título:
Invited speaker: Combinatorial biosynthesis of modular polyketide synthase genes
Autor/es:
HUGO MENZELLA
Lugar:
Prague, Czech Republic
Reunión:
Congreso; 10th International Symposium on the Genetics of Industrial Microorganisms.; 2006
Resumen:
Combinatorial biosynthesis can refer to any strategy for thegenetic engineering of natural product biosynthesis to obtainnew molecules, including the use of genetics for medicinalchemistry. However, it also implies the possibility that largelibraries of complex compounds might be produced to feed amodern high-throughput screening operation. This reviewfocuses on the multi-modular enzymes that producepolyketides, nonribosomal peptides, and hybrid polyketidepeptidecompounds, which are the enzymes that appear to bemost amenable to truly combinatorial approaches. The recentestablishment of a high-throughput strategy for testing theactivity ofmanynon-natural combinations ofmodules fromtheseenzymes should help speed the advance of this technology.