INVESTIGADORES
MENZELLA Hugo Gabriel
artículos
Título:
Heterologous Production of Polyketides in Bacteria
Autor/es:
RODRIGUEZ E.; MENZELLA H. G.; GRAMAJO H.
Revista:
METHODS IN ENZYMOLOGY.
Editorial:
ELSEVIER ACADEMIC PRESS INC
Referencias:
Año: 2009 vol. 459 p. 339 - 365
ISSN:
0076-6879
Resumen:
Polyketide natural products are among the most important microbial metabolitesin human medicine and are widely used to treat both acute and degenerativediseases. The need to develop new drugs has prompted the idea of usingheterologous systems for the expression of polyketide biosynthetic pathways.The basic idea behind this approach is to use heterologous bacterial systemswith better growth and genetic characteristics that could support betterproduction of a certain compound than the original host or that couldallow the generation of novel analogues through combinatorial biosynthesis.
