Antifungal activity of Heterothalamus alienus metabolites

PACCIARONI, A.; GETTE, M.; DERITA, M.; ARIZA-ESPINAR, L.; GIL, R.; ZACCHINO, S.; SILVA, G.

PHYTOTHERAPY RESEARCH

Wiley Interscience

Lugar: San Francisco CA.; Año: 2008 vol. 22 p. 524 - 528

0951-418X

The chemical study of Heterothalamus alienus gave rutin, spathulenol (1), (1R,7S)-germacra-4(15),5,10(14)-trien-1B-ol (2), sakuranetin (3), padmatin 3-acetate (4), (2R,3R)-dihydroquercetin-7,3´,4´-trimethyl ether (5), (2R,3R)-dihydroquercetin-7,4´-dimethyl ether (6), (2R,3R)-3-acetoxy-5,7,4´-trihydroxyflavanone (7), as the main components of an antifungal extract of the aerial parts of the plant. Compound 2 showed moderate activity, with Epidermophyton floccosum being the most susceptible species (MIC = 100 ug/mL; compound 3 showed the best antifungal behavior having a broad spectrum of action and the lowest MICs. This flavanone along with flavanolol 5 showed very good activity against standardized (MIC = 31.2 ug/mL) as well as clinical isolated of Trichophyton rubrum and T. mentagrophytes (MIC ranges 31.2-62.5 ug/mL and 31.2-125 ug/mL, respectively) and demonstrated not only fungistatic but also fungicide properties. Flavanolol 6 was active against all the dermatophytes tested with MICs of 62.5-250 ug/mL. Rutin, spathulenol (1) and the 3-acetylated flavanones 4 and 7 were inactive or marginally active against the fungal panel.