Nano-in-nano enteric delivery sytem

SONZOGNI, ANA S.; RIVERO GUADALUPE; MINARI, ROQUE J.; GONZALEZ, VERÓNICA D.G.; ABRAHAM, GUSTAVO A.; CALDERÓN, MARCELO

Conferencia; 4th Spanish Conference on Biomedical Applications of Nanomaterials (SBAN 2021); 2021

The use of nanoparticles to selectively deliver therapeutics to specific sites has been the key for achieving effective treatments and reducing adverse effects. Nanogels (NGs), polymer crosslinked nanoparticles, have a leading role in controlled and targeted release, because they offer high water retention resulting in high loading capabilities, stability in biological fluids and biocompatibility. But despite their great advantages, their used for oral delivery is limited due to their large exposed area and porosity that do not allow to protect their cargo from the extreme conditions of the stomach. In this work, the development of a nano-in-nano polymer system for protein enteric delivery is presented.