A multiparametric model for an electrostatic dripping process coupled to a sol-gel transformation useful to describe the formation of hydrogel microbeads.

JUAN CARLOS ILARDO; IGNACIO RINTOUL

Simposio; 1st PhD Student Symposium on ?Materials for Energy, Environment and Health? ? AUGM-BAYLAT; 2021

AUGM BAYLAT

Poly(vinylalcohol) (PVA) hydrogels in the form of microbeads find importantapplications in regenerative medicine and controlled drug deliverytechnologies. Electrostatic dripping of a PVA-levamisole aqueoussolution followed by a sol-gel transformation of the generatedmicrodrops is a useful technique to obtain microbeads with controlledsize, size distribution and tailored gel structures. However, therelationship between the conditions of the electrostatic drippingprocess coupled to the sol-gel transformation with the resultingproperties of the obtained microbeads is not fully understood anddeserves investigation. Levamisole is a well-known antiparasitewidely used in human and animal health. PVA is a versatilehydrosoluble and biocompatible polymer.Theobjective of this contribution is the establishment of thecross-functionality of the main variables of an electrostaticdripping process coupled to a sol-gel transformation reaction in thesize, shape and structural parameters of resulting PVA-levamisolemicrobeads. Methodology:The experimental set-up includes the preparation of a PVA-levamisolesolution, a receiving bath to induce the gelation of the drippingsolution and the electrostatic dripping device. The conditions of theelectrostatic dripping process and the sol-gel transformation wereselected by following an experimental design. The voltage, frequency,flow and temperature of the dripping solution and the pH,temperature, ionic strength and surfactant concentration of thereceiving gelling bath were used as main raw data generator for theelectrostatic dripping process and the sol-gel transformation,respectively. Results:A 4-D surface response of size, shape and structural properties ofresulting PVA-levamisole microbeads in the space of the electrostaticdripping process and sol-gel transformation variables was obtained.The 4-D surface response in the space of the electrostatic drippingprocess variables and the sol-gel transformation conditions canpredict very precisely the characteristics of PVA-levamisole hydrogelmicrobeads.Futurecontributions will be devoted to the study the effect of size, shapeand gel structure properties of microbeads on their kinetics oflevamisole release.p { margin-bottom: 0.25cm; direction: ltr; color: #000000; line-height: 120%; orphans: 2; widows: 2 }p.western { font-family: "Liberation Serif", serif; font-size: 12pt; so-language: en-US }p.cjk { font-family: "Noto Sans CJK SC Regular", "Times New Roman"; font-size: 12pt; so-language: zh-CN }p.ctl { font-family: "FreeSans", "Times New Roman"; font-size: 12pt; so-language: hi-IN }a.western:link { so-language: zxx }a.ctl:link { so-language: zxx }