Structure and properties of biocompatible poly(glycerol adipate) elastomers modified with ethylene glycol.

LUCILA NAVARRO; NATALIA, CEAGLIO; IGNACIO RINTOUL

POLYMER JOURNAL

SOC POLYMER SCIENCE JAPAN

Año: 2017 vol. 49 p. 625 - 632

0032-3896

p { margin-bottom: 0.25cm; line-height: 120%; }Polyesterspoly(glycerol adipate)s or PGAs were prepared through a catalyst-freepolycondensation reaction involving different proportions of adipicacid and glycerol. Additionally, another set of PGAs was formulatedby adding ethylene glycol to the reaction mixture, creating threePGA-co-ethylene glycols of different ethylene glycol-to-glycerolratios. All prepolymers were chemically crosslinked into elastomericfilms according to specific experimental conditions. A fullcharacterization of elastomers revealed an ease of tunabilityaccording to monomer ratios and curing conditions. Mechanicalproperties presented a variety of Young?s modulus values rangingfrom 0.07 to 8.33 MPa. Within this range, a number of Young?smodulus values of soft tissues can be included. Moreover, acytotoxicity analysis performed on embryonic mouse fibroblasts(NIH/3T3) showed an absence of cytotoxicity and good adherence overall PGA and PGA-co-ethylene glycol elastomers. In addition,fibroblasts underwent a differentiation process into neuron-likecells, thus exhibiting excellent potential for soft tissueengineering.