Three Topical Protein Delivery Systems Based on Poly(N-Vinylcaprolactam)

SONZOGNI, A. S.; GUGLIOTTA, L.M.; CALDERON, M.; GONZALEZ, V.D.G.; MINARI, R.J.

Córdoba

Simposio; XII Simposio Argentino de Polímeros (SAP 2017); 2017

Universidad Nacional de Cordoba

Topical delivery routes have a lot of advantages over other types of therapeutic agent delivery modalities suchoral, intravenous, intramuscular, etc. Some positive features of this application route are the avoidance offirst pass metabolism, of gastrointestinal incompatibility, drug level fluctuation, while minimizing undesirableside effect and providing a self-administration suitability [1]. Different designs of topical delivery systemswere developed in order to improve their application, such as the cases of hydrogels in macro- and nanoscales(nanogels) [2, 3].In this work, the performance of a novel platform for topical protein delivery is compared with macrogels andnanogels, two well-known and studied systems. This platform consists in a nanostructured patch obtainedfrom dispersed hybrid nanogels with film forming ability and thermosensitive properties. The three systemsare based in poly(N-vinylcaprolactam), that give them thermosensitive properties, while the hybrid nanogelsalso contains poly(butyl acrylate) and poly(acrylic acid) to facilitate the patch formation, by particlescoalescence, and the skin adhesion. Transition temperature, cytotoxicity, in vitro ovalbumin (as modelprotein) release-profile and ovalbumin skin penetration were evaluated and compared amongst the threesystems. All the formulations resulted thermosensitive, non-cytotoxic and able to load and release ovalbumin.The use of the nanostructured patch in topical delivery studies showed that skin penetration of ovalbumin washigher than that obtained with pure ovalbumin, and with nanogels and macrogels as supports