Hybrid Thermosensitive-Nanogels based on N-vinylcaprolactam

SONZOGNI, A. S.; GONZALEZ, V. D. G.; VAILLARD, S. E.; PASSEGGI, M.C.G.; GUGLIOTTA, L. M.; MINARI, R. J.

Porto do Galinhas, PE, Brazil

Simposio; XIV Latin American Symposium on Polymers (SLAP 2014)/ and XII Ibero American Congress on Polymers; 2014

Asociación Brasileña de Polímeros

This work presents a semibatch strategy to produce hybrid nanogels with core-shell morphology. The synthesized nanogels have a core of poly(N-vinylcaprolactam) (PVCL), a biocompatible polymer with a phase transition close to the physiological temperature, and a shell of poly(butyl acrylate) (PAcBut) that provides the properties of adhesiveness and film formation. These nanogels could be directly used in transdermal drug release, without requiring a support and adhesive matrix. Morphology, mean particle diameter and thermal response of the nanogels were evaluated along the work.