INFERTILITY IN A MODEL OF DIET-INDUCED OBESITY IN MALE B6 MICE.

? ALTAMIRANO L,; ? SIMÓN L, ; ? SÁEZ E,; DELLA-VEDOVA, MC; GOMEZ-MEJIBA S.E; RAMIREZ D.C,; MIGUEL W. FORNES

Congreso; SBC; 2013

Obesity and overweight are known causes of infertility in men,but the mechanism involved remains unknown. The aim of thisstudy was to evaluate the redox profile/ inflammatory/metabolicsystemic and testicular morphological abnormalities that couldexplain the sub-fertility. Mice model included 2 groups: LFD(low fat diet) and HFD (high-fat diet). At 18 weeks HFD groupshowed an increase in proinflammatory cytokines (TNF-a andIL-6) and oxidative stress markers (carbonyl and TBARS)levels. Basal fasting blood glucose and intraperitoneal glucosetolerance tests showed insulin resistance in HFD group.Epididymal fat weight was greater in HFD, and testicles showedfoam cells in the interstitium. The spermato/spermiogenesisshowed patchy epithelial disorganization, and abnormalspermatocytes with abnormal acrosome complex-acroplaxoma.These data suggest that the abnormalities found inspermatogenesis may be caused by changes inredox/inflammatory/metabolic status in testis, reflecting thesystemic situation associated to inflammation of the adiposetissue.