EFFECT OF AN I.C.V. INJECTION OF AGREGATED BETA-AMYLOID (1-42) ON THE DAILY LEVELS OF IL-6, TNF-a IN THE RAT HIPPOCAMPUS005 - EFFECT OF AN I.C.V. INJECTION OF AGREGATED BETA-AMYLOID (1-42) ON THE DAILY LEVELS OF IL-6, TNF-a IN THE RAT HIPPOCAMPUS Co

CORTEZ M; IBANEZ J; RODRIGUEZ BRITOS A; TORALES P; ALBA R; LEDEZMA C; CORIA LUCERO C; PEREZ C, ; ALVAREZ S; RAMIREZ D; GOMEZ MEJIBA S, ; DELGADO S.; ANA ANZULOVICH; LORENA NAVEGATORE-FONZO

san luis

Congreso; SBC; 2024

005 - EFFECT OF AN I.C.V. INJECTION OF AGREGATED BETA-AMYLOID (1-42) ON THE DAILYLEVELS OF IL-6, TNF-α IN THE RAT HIPPOCAMPUSCortez M, Sanchez Vela M, Ibanez J, Rodriguez Britos A, Torales P, Alba R, Ledezma C, Coria Lucero C, Perez C, Alvarez S, Ramirez D, GomezMejiba S, Delgado S, Anzulovich A and Navigatore Fonzo LLaboratorio de Cronobiología, IMIBIO-SL, CONICET-UNSL. UNViMe E-mail: lorenavigfz@yahoo.com.ar.Alzheimer’s disease (AD) is one of the common forms of dementia. In the progression of AD, it has been demonstrated that accumulation andaggregation of Aβ peptide in the brain, initiates a neuroinflammatory response, involving inflammatory cytokines, including interleukin (IL) IL-6 andtumor necrosis factor (TNF-α). Besides cognitive deficits, AD patients show alterations in their circadian rhythms. The objective of this study was toinvestigate the effects of an intracerebroventricular (i.c.v.) injection of amyloid beta peptide (1-42) on daily patterns of IL-6, TNF-α levels, as well asof Bmal1 expression in the hippocampus and on temporal profiles of cognitive performance. Groups were defined as: control (CO) and Aβ-injected(Aβ). Rats were maintained under 12 h-light:12 h-dark conditions and received food and water ad libitum throughout the entire experimental. For theNovel Object Recognition (NOR) test, the experimental findings were evaluated by analysis of ANOVA with repeated measures followed byBonferroni’s post-hoc test for specific comparisons, a p