Pulmonary Neutrophilic Inflammation Worsens Obesity-Associated Comorbidities

BARRERAS, FS; DARIO C RAMIREZ; GOMEZ MEJIBA, SANDRA;

PREPRINTS.ORG

Editorial Board Members

Lugar: BASEL; Año: 2025

2310-287X

Abstract: Obesity has emerged as a significant global health challenge characterized by excessive fataccumulation and a complex interplay of systemic inflammation and metabolic dysregulation. Thiscondition not only impacts overall health but also affects various organ systems, including the lungs.Recent research highlights how obesity influences lung health through mechanisms involvingmechanics and chronic low-grade inflammation, which can alter pulmonary structure and function.Despite increasing evidence that inflammation in adipose tissue plays a crucial role in systemicmetabolic disturbances, our understanding of its relationship with pulmonary neutrophilicinflammation remains limited. There is a need to explore how adipose tissue inflammation interactswith pulmonary physiology, particularly in the context of obesity-associated metabolic risk. Byinvestigating the mechanisms underlying pulmonary neutrophilic inflammation, we can identifypotential therapeutic targets to mitigate pulmonary dysfunction, as well as obesity-associatedmetabolic risk. This review emphasizes the importance of adipose tissue-derived inflammatorymediators in pulmonary neutrophilic inflammation in obesity-associated metabolic comorbidities.Keywords: obesity; adipose tissue inflammation; pulmonary neutrophilic inflammation; systemicinflammation; obesity-associated metabolic comorbidity; insulin resistance