INVESTIGADORES
GOMEZ-MEJIBA sandra Esther
artículos
Título:
Impact of Nrf2 Signaling Pathway in Adipogenesis and Its Role in Insulin Resistance Associated with Obesity
Autor/es:
CARLA F. GUZMAN ; DARIO C. RAMIREZ *; SANDRA E. GOMEZ MEJIBA
Revista:
PREPRINTS.ORG
Editorial:
Editorial Board Members
Referencias:
Lugar: Basilea; Año: 2025
ISSN:
2310-287X
Resumen:
Abstract: A chronic positive energy balance, as observed in obesity, leads to an increase in circulatingfree fatty acids (FFAs), which can activate inflammatory signaling in M1 macrophages. Nuclear factorerythroid 2-related factor 2 (Nrf2) is a transcription factor that controls the expression of several genesinvolved in the cellular response to redox changes, xenobiotic detoxification, and adipogenesis. Thesignaling pathway that leads to the migration of Nrf2 to the cell nucleus is well known, but its role inregulating the adipogenesis process remains controversial. Activation of the Nrf2 signaling pathwayleads to increased expression of critical enzymes involved in FFA esterification, such as triglycerides,the safest way to store FFAs. This paper reviews recent information on the role of Nrf2 in thedifferentiation of preadipocytes into adipocytes, which helps explain controversial information.Adipocytes specialize in storing FFAs as triglycerides and act as endocrine cells. However, in obesity,its functions are dysregulated along with the macrophage-induced inflammation of adipose tissue.Adipose tissue inflammation is the main cause of low-grade systemic inflammation observed in obesepatients and the main link between adipose tissue inflammation and obesity-associated insulinresistance. Therefore, a deeper understanding of the role of Nrf2 in the process of adipogenesis isessential for the development of new agonists to prevent metabolic abnormalities associated withobesity.Keywords:
