INVESTIGADORES
GOMEZ-MEJIBA sandra Esther
artículos
Título:
VITAMIN A DEFICIENCY CAUSES APOPTOSIS IN THE MAMMARY GLAND OF RATS
Autor/es:
VASQUEZ-GOMEZ M ; FILIPPA, V.; ACOSTA M; MOHAMED ; CAMPO VERDE F; FERRARI C.; JAHN G.A.; GIMÉNEZ M.S; RAMIREZ D.C; GOMEZ MEJIBA, S.E.
Revista:
BIORXIV
Editorial:
COLD SPRING HARBOR LABORATORY
Referencias:
Año: 2024
ISSN:
2692-8205
Resumen:
ABSTRACTSubchronic dietary vitamin A deficiency (VAD) causes severe abnormalities, includingdysfunction of the epithelia of the mammary gland. However, the underlying mechanism ofthis process is partially known. Therefore, herein, we used a nulliparous-rat experimentalmodel of dietary VAD for a total dieting regime of 3 and 6 months and intervened (refeed)with a vitamin A sufficient (VAS) diet for 0.5 or 1 month before the end of the diet regimeand investigated the underlying molecular mechanism of mammary tissue dysfunction.Dietary vitamin A deficiency for 3 and 6 months caused increased inflammatory cellinfiltration in the mammary gland parenchyma and glandular cells, with increasedinflammation and apoptosis and reduced cell proliferation. These changes can be reversedwith a VAS diet. Mammary gland dysfunction after a subchronic VAD is caused by animbalance between NFκB and retinoic acid-triggered signaling. Inflammation, apoptosis,and impaired proliferation lead to dysfunction of the epithelia of the mammary gland ofnulliparous rats fed a VAD diet.
