INVESTIGADORES
FRONTINI patricia Maria
congresos y reuniones científicas
Título:
Development of well-aligned nanofibrous membranes for wound healing
Autor/es:
F. MONTINI BALLARIN; GUSTAVO A. ABRAHAM; FRONTINI, PATRICIA; S..C. WONG
Lugar:
Boston
Reunión:
Congreso; MRS Fall Meeting; 2010
Resumen:
Recently, wound healing has gained much attention due to the development of novel materials in the nanoscale size with small pores, excellent pore-interconnectivity, very high specific surface area, great mechanical, and absorptive properties. The adhesion properties of wound dressings are important for future biomedical applications; in particular, for a good adhesion to the tissue that is healing and a reduced adhesion with time. Based on bioinspired dry adhesion of natural creatures, we developed a well-aligned nanofibrous membrane by electrospinning. The electrospinning setup consists of a tip collector (a wire grounded electrode inside a wooden board), a high voltage power supply, a nozzle, and a support plate. The influence of solution intrinsic properties and process parameters on the membrane morphology and properties was studied and optimized to produce aligned uniform bead-free fiber morphology. The adhesion properties of the membranes were measured by an adhesion peel test. The effect of the peeling rate and dwell time was studied. Some bulk and random nanofibrous membranes were prepared in order to compare the adhesion strength with the aligned ones. Morphological characterization of electrospun membranes, before and after testing, was carried out by Scanning Electron Microscopy (SEM).