LIPOPOLYSACCHARIDE-INDUCED MURINE EMBRYONIC RESORPTION INVOLVES CHANGES IN ENDOCANNABINOID PROFILING AND ALTERS PROGESTERONE SECRETION AND INFLAMMATORY RESPONSE BY A CB1-MEDIATED FASHION

WOLFSON MANUEL LUIS; CORREA FERNANDO GABRIEL; LEISHMAN EMMA; VERCELLI, CLAUDIA; CYMERYNG CORA; BLANCO JULIETA; BRADSHAW H.B; FRANCHI, ANA MARIA

MOLECULAR AND CELLULAR ENDOCRINOLOGY.

ELSEVIER IRELAND LTD

Lugar: Amsterdam; Año: 2015

0303-7207

Genital tract infections are a common complication of human pregnancy that can result in miscarriage. We have previously shown that a lipopolysaccharide (LPS) induces embryonic resorption in a murine model of inflammatory miscarriage. This is accompanied by a dramatic decrease in systemic progesterone levels associated with a robust pro-inflammatory response that results in embryo resoprtion. Here, we tested the hypothesis that the endogenous cannabinoid system (eCS), through cannabinoid receptor 1 (CB1), plays a role in regulating progesterone levels and, therefore, the pro-inflammatory response. We show that LPS treatment in pregnant mice causes significant changes in the eCS ligands, which are reversed by progesterone treatment. We further show the CB1-KO mice maintain higher plasma progesterone levels after LPS treatment, which is associated with a feebler uterine inflammatory response and a significant drop in embryo resorption. These data suggest that manipulation of CB1 receptors and/or ligands is a potential therapeutic avenue to decrease infection-induced miscarriage.