The initial inactivation of prostaglandins (PG) is mediated by 15-hydroxyprostaglandin dehydrogenase (15-PGDH). Prostaglandins are potent mediators of several biological processes, including inflammation and reproduction. In uterus, prostaglandins play a

JAWERBAUM ALICIA; FRANCHI, ANA MARIA; GONZALEZ ELIDA; NOVARO VIRGINIA; GIMENO MARTA

PROSTAGLANDINS.

ELSEVIER Science Inc.

Año: 1995 vol. 50 p. 47 - 56

0090-6980

The relationship between high glucose concentrations and arachidonicacid metabolism in uterine tissue from control and diabetic ovariectomizedrats was evaluated. Uterine tissue from diabetic rats producedamounts of PGE, and PGFe, similar to controls, while a lower productionof 6keto-PGF,, (indicating the production of prostacyclin) and ahigher production of TXB, (indicating the generation of TXA,) wasfound in the diabetic group. A group of diabetic rats was treated withphlorizin to diminish plasma glucose levels. Phlorizin treatment didnot alter production of PGE,, PGF,,, and 6-keto-PGF,, in the diabeticgroup. A diminished production of TXB, was found in the treated diabeticuteri when compared to the non-treated diabetic group. Moreover,a positive correlation between plasma glucose levels and uterineTXB, generation was observed. When control uterine tissue was exposedin vitro to high concentrations of glucose (22 mM) and comparedto control tissue incubated in the presence of glucose 11 mMalterations in the generation of PGE, PGF,,, and 6-keto-PGF,, werenot found, but a higher production of TXB, was observed and valueswere similar to those obtained in the diabetic tissue. Alteration in theproduction of the prostanoids evaluated were not observed when diabetictissue was incubated in the presence of high concentrations ofglucose.