INVESTIGADORES
GORLA Nora Bibiana Maria
artículos
Título:
Sister-chromatid exchange in spleenic lymphocytes of mice after exposure to nifurtimox or benznidazole
Autor/es:
GORLA NORA B M
Revista:
MUTATION RESEARCH
Editorial:
eLSEVIER
Referencias:
Año: 1987
ISSN:
0921-8262
Resumen:
The induction of sister-chromatid exchange (SCE) was analyzed in spleenic lymphocytes of mouse after exposure to nifurtimox (NFX) or benznidazole (BZ). Lymphocytes from Swiss mice treated ?in vivo? with 1200 and 2000 mg/kg NFX (p.o.) and then incubated ?in vitro? with bromo-2´-deoxyuridine showed an increased frequency of SCE. No significant differences were observed in mice treated with 2000 mg/kg BZ (p.o). The present and previous results obtained in this and other laboratories suggest that the effects observed should wam against the potential risk of NFX treatment in humans receiving this chemo- therapeutic agent as a treatment for Chagas? disease.
