INVESTIGADORES
GORLA Nora Bibiana Maria
artículos
Título:
OXIDATIVE STRESS AND COMET ASSAY IN TISSUES OF MICE ADMINISTERED GLYPHOSATE AND AMPA IN DRINKING WATER FOR 14 DAYS
Autor/es:
FERNANDO MAÑAS 1 , LAURA PERALTA 1 , LAURA UGNIA 2 , ALICIA WEYERS 2 , HUGO GARCÍA OVANDO 1 , NORA GORLA
Revista:
journal of basic and applied genetics
Editorial:
sociedad argentina de genética
Referencias:
Año: 2013 vol. 24 p. 67 - 75
ISSN:
1853-7138
Resumen:
Excessive amounts of the herbicide glyphosate are incorporated daily to the soil and the ecosystems. AMPA is its major environmental breakdown product. In this study we determined the levels of thiobarbituric acid reactive substances (TBARs); quantified superoxide dismutase (SOD) and catalase (CAT) activity in liver, kidney, lung and heart, and performed the comet assay in blood and liver of mice administered glyphosate (40 or 400 mg/kg/day) or AMPA (100 mg/kg/day) in drinking water for 14 days. Exposure to glyphosate 400 mg/kg induced a statistically significant (p
