INVESTIGADORES
GORLA Nora Bibiana Maria
artículos
Título:
THIRTEENFOLD INCREASE OF CHROMOSOMAL ABERRATIONS NON RANDOMLY DISTRIBUTED IN CHAGASIC CHILDREN TREATED WITH NIFURTIMOX.
Autor/es:
GORLA N B, LEDESMA O S, BARBIERI P, LARRIPA I.
Revista:
MUTATION RESEARCH-GENETIC TOXICOLOGY
Editorial:
ELSEVIER
Referencias:
Año: 1989 vol. 224 p. 263 - 267
ISSN:
0165-1218
Resumen:
Chromosomal aberrations were analyzed from cultures of peripheral lymphocytes in 2 groups of chagasic children, before and after treatment with nifurtimox. The mean incidence of chromosomal aberrations increased from control values of 1.75 ± 1.39 (8 patients) to 23.55 ± 9.55 (6 patients) at a significance of P < 0.0001. G-banding analysis of chromosomal aberration sites revealed that treated patients present coincidence in the chromosome regions affected: 1p11, 1q11–12, 9q11–13, 17q11–21, 2p21, 2q23, 2q31, 2q33, 6p21, 6q21, 7q32, 13q14, 13q22, 15q22. These data indicate a non-random distribution of chromosomal aberrations induced by nifurtimox therapeutic treatment.