INVESTIGADORES
GORLA Nora Bibiana Maria
artículos
Título:
Chromosomal aberrations in human lymphocytes exposed in vitro to enrofloxacin and ciprofloxacin
Autor/es:
GORLA N, GARCÍA OVANDO H, LARRIPA I
Revista:
TOXICOLOGY LETTERS
Editorial:
ELSEVIER IRELAND LTD
Referencias:
Año: 1999 vol. 104 p. 43 - 48
ISSN:
0378-4274
Resumen:
Abstract Chromosomal aberrations were evaluated in cultures of human peripheral lymphocytes from eight healthy donors, exposed to the antimicrobial enrofloxacin (EFX) or to its major metabolite ciprofloxacin (CFX). In both treatments cultures revealed an increase in the chromosomal aberration level, detected as chromatid and chromosome breaks and gaps. Control cultures analysis revealed 3.6±0.6 chromosomal aberrations per 100 cells while treated cultures exhibited 8.3±0.8 and 9.6±1.2 aberrations at 5 and 50 ìg/ml of EFX respectively. In CFX treated cultures it was found 5.6±1.3 and 7.7±3.5 aberrations/ 100 cells at 5 and 25 ìg/ml antimicrobial concentration. These results suggested a genotoxic effect of EFX and CFX in the system used (P