Antiprotozoal activity of flavonoids from Eupatorium arnottianum

CLAVIN ML; CAZORLA SI; SPINA R; SOSA MA; MALCHIODI EL; MARTINO VS; FRANK FM *; LILIANA MUSCHIETTI *

Journal of Parasitic Diseases: Diagnosis and Therapy

Allied Academies

Lugar: Londres; Año: 2016 vol. 1 p. 1 - 6

Dichloromethane and ethanol extracts of Eupatorium arnottianum were evaluated for invitro leishmanicidal activity. The dichloromethane extract produced 80% and 85% of growth inhibition on both Leishmania mexicana and Leishmania amazonensis promastigotes respectively, at a concentration of 100 μg/mL. At the same concentration, the ethanol extract inhibited the growth of L. mexicana and L. amazonensis promastigotes in 62% and 65% respectively. Bioassayguided fractionation of these extracts led to the isolation and identification of flavonoids nepetin, eupatilin, jaceosidin, eriodictyol and hyperoside as bioactive compounds against both species of Leishmania with IC50 values