IMMUNOMODULATORY PROPERTIES OF PROSTAGLANDIN E2 ON NEUTROPHILS DURING HUMAN TUBERCULOSIS INFECTION.

JOAQUIN PELLEGRINI; FLORENCIA SABBIONE; MARIA PAULA MORELLI; CASTELLO FLORENCIA; NANCY L. TATEOSIÁN; AMIANO NICOLAS; A LORENA CIALLELA,; ALBERTO LEVI; DOMINGO J. PALMERO; ANALIA TREVANI; GARCÍA V.E

Congreso; Reunión conjunta SAIC-SAI-SAFIS 2018; 2018

Immunomodulatory properties of prostaglandin E2 on human neutrophils during tuberculosis infectionPellegrini, Sabbione, Morelli, Castello, Tateosian, Amiano, Cialela, Levi, Palmero, Trevani, García.Keywords: tuberculosis; neutrophils; prostaglandin E2During Mycobacterium tuberculosis (Mtb) infection, neutrophils are among the first cells that migrate to the infectious focus and represent the most abundant cell population harboring Mtb in samples from patients with active tuberculosis (TB). Neutrophilic infiltration and exuberant inflammation represent characteristic features of severe TB, but neutrophils biology during TB remains poorly understood. Prostaglandin E2 (PGE2), an active lipid compound derived from arachidonic acid, is a key mediator of immunopathology in chronic infections and cancer by regulating different stages of immune responses. Manipulation of PGE2 levels was proposed as an approach for countering the Type I IFN signature of TB patients and to alleviate active TB disease, but very limited information exists about this pathway in patients with active TB. The aim of this work was to investigate the role of PGE2 on modulation of human neutrophil immune responses against Mtb. Our results indicate that the number of neutrophils was significantly higher in patients with positive Acid Fast Bacilli (AFB) in sputum, as compare to AFB negative TB patients (p