THE IL-17F rs763780 SNP IS ASSOCIATED WITH HUMAN TUBERCULOSIS SUSCEPTIBILITY AND DISEASE SEVERITY IN ARGENTINA.

ROLANDELLI AGUSTIN; JOAQUIN PELLEGRINI; SANTILLI, MARÍA C.; AMIANO NICOLAS; CASTELLO FLORENCIA; MARIA PAULA MORELLI; N. TATEOSIAN; CASCO, NICOLÁS; ALBERTO LEVI; DOMINGO J. PALMERO; GARCÍA VERÓNICA

Congreso; LXV Reunión Anual de la Sociedad Argentina de Inmunología durante la I Reunión Conjunta de Biociencias.; 2017

THE IL-17F rs763780 SNP IS ASSOCIATED WITH HUMAN TUBERCULOSIS SUSCEPTIBILITY AND DISEASE SEVERITY IN ARGENTINA.Mycobacterium tuberculosis (Mtb) causes nearly 10 millions of new tuberculosis disease cases annually. However, most individuals exposed to Mtb do not develop tuberculosis, suggesting the influence of a human genetic component. In this work, we investigated the association of the IL-17F rs763780 SNP (TC), which generates a protein that is a natural IL-17F antagonist, with tuberculosis disease in Argentina. We found that individuals carrying the C allele were overrepresented in the TB population (TB N=201; HD N= 200; p