Signaling pathways that regulate restimulation-induced cell death in tuberculosis patients

HERNÁNDEZ DEL PINO, RODRIGO E; ROVETTA A; JOAQUIN PELLEGRINI; SOMOZA MARTIN; AMIANO NICOLAS; DOMINGO PALMERO; ALEJANDRO MALBRÁN; GUTIERREZ MARISA; PASQUINELI, V; VERONICA E GARCIA

Congreso; LXII Reunión Científica Anual de la Sociedad Argentina de Inmunología (SAI).; 2014

Resumen : NK, T, B cell antigen (NTB-A) and SLAM associated protein (SAP) expression are required for T cell restimulation-induced cell death (RICD). We reported that T cells from Low responder (LR) tuberculosis (TB) patients displayed higher levels of SAP mRNA and protein than healthy donors (HD) and High responder (HR) TB patients. Here, we evaluated cell loss in restimulated cells to address whether SAP is directly required for RICD using X-linked lymphoproliferative (XLP) patients (SAP-deficient patients). XLP patients displayed between 35-50% cell loss after restimulation, while HD and HR patients showed 70-90% cell loss (p