PD-1 modulates the expansión of Th1/Th17 populations during active tuberculosis

JAVIER O JURADO; IVANA B. ÁLVAREZ; DELFINA PEÑA; ANA I. ROVETTA; RODRIGO HERNANDEZ DEL PINO; JORGE P. CASTAGNINO; ROSA MARÍA MUSELLA; VIRGINIA PASQUINELLI; VERÓNICA E. GARCÍA

Buenos Aires

Congreso; 1er Congreso Franco-Argentino de Inmunología; 2010

An appropriate immune response against M. tuberculosis (Mtb) requires Th1 cytokine responses; in particular, IFN-g. However, although this cytokine displays a crucial role, its secretion is not enough to achieve a complete protection against the pathogen. Accordingly, it was shown that IL-17 produced by CD4 T cells would be required to eliminate primary infection. Besides the existence of Th1 and Th17 populations, another subset of CD4+IFN-g. +IL-17+ cells was described. Thus, here we analyzed the role of CD4+ cells during active tuberculosis (TB). Stimulation of PBMC with the specific Ag (Mtb) induced significantly higher levels of IL-17 from TB patients compared to healthy donors (HD) (TB: 414±79pg/ml; HD: 276±45pg/ml; p