Antioxidan and Cytotoxic Activity of Canadine. Biological Effects and Structural Aspects

E. CORRECHE, S.ANDUJAR, R.KURDELAS, M.J.GOMEZ LECHON, M.L.FREILE AND R.D.ENRIZ

BIOORGANIC & MEDICINAL CHEMISTRY.

Elsevier

Lugar: Amsterdam; Año: 2008 vol. 16 p. 3641 - 3651

0968-0896

Abstract—The cytotoxic effects of four alkaloids, berberine, canadine, anonaine, and antioquine were evaluated using three different  cell cultures, a primary culture (rat hepatocytes) and two cell lines (HepG2 and HeLa). Our results indicate that berberine, anonaine, and antioquine possess a significant the cytotoxic effect. In contrast, canadine does not possess cytotoxic effect at concentrations tested here. A molecular modeling study indicates that the quaternary nitrogen, the aromatic polycyclic and planar structure of berberine- cell cultures, a primary culture (rat hepatocytes) and two cell lines (HepG2 and HeLa). Our results indicate that berberine, anonaine, and antioquine possess a significant the cytotoxic effect. In contrast, canadine does not possess cytotoxic effect at concentrations tested here. A molecular modeling study indicates that the quaternary nitrogen, the aromatic polycyclic and planar structure of ber- The cytotoxic effects of four alkaloids, berberine, canadine, anonaine, and antioquine were evaluated using three different  cell cultures, a primary culture (rat hepatocytes) and two cell lines (HepG2 and HeLa). Our results indicate that berberine, anonaine, nd antioquine possess a significant the cytotoxic effect. In contrast, canadine does not possess cytotoxic effect at concentrations that the potential of this alkaloid as a novel class of antioxidant agent is very interesting and deserves further research. The cytotoxic effects of four alkaloids, berberine, canadine, anonaine, and antioquine were evaluated using three different  cell cultures, a primary culture (rat hepatocytes) and two cell lines (HepG2 and HeLa). Our results indicate that berberine, anonaine, nd antioquine possess a significant the cytotoxic effect. In contrast, canadine does not possess cytotoxic effect at concentrations that the potential of this alkaloid as a novel class of antioxidant agent is very interesting and deserves further research. The cytotoxic effects of four alkaloids, berberine, canadine, anonaine, and antioquine were evaluated using three different  cell cultures, a primary culture (rat hepatocytes) and two cell lines (HepG2 and HeLa). Our results indicate that berberine, anonaine, nd antioquine possess a significant the cytotoxic effect. In contrast, canadine does not possess cytotoxic effect at concentrations that the potential of this alkaloid as a novel class of antioxidant agent is very interesting and deserves further research.