INVESTIGADORES
ENRIZ Ricardo Daniel
artículos
Título:
In Vitro Antifungal Activity of New Series of Homoallylamines and Related Compounds with Inhibitory Properties of the Synthesis of Fungal Cell Wall Polymers
Autor/es:
L. VARGAS; M.V CASTELLI; V. KOUZNETSOV; J URBINA; S.LOPEZ; M. SORTINO; R D ENRIZ; J C RIBAS; S ZACCHINO
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY.
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2003 vol. 11 p. 1531 - 1550
ISSN:
0968-0896
Resumen:
The synthesis, in vitro antifungal evaluation and SAR studies of 101 compounds of the 4-aryl-, 4-alkyl-, 4-pyridyl or-quinolinyl-4-N-arylamino-1-butenes series and related compounds, are reported here. Active structures showed to inhibit (1,3)-b-dglucanand mainly chitin synthases, enzymes that catalyze the synthesis of the major fungal cell wall polymers.
