Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents

” F.D SUVIRE, M SORTINO, V.V. KOUZNETSOV, L.Y VARGAS, S ZACCHINO, R.D.ENRIZ

BIOORGANIC & MEDICINAL CHEMISTRY.

Elsevier

Lugar: Amsterdam; Año: 2006 vol. 14 p. 1851 - 1862

0968-0896

PROOF —The synthesis, in vitro evaluation, and structure–activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)- acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)- The synthesis, in vitro evaluation, and structure–activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)-N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)- N-(2-furylmethyl)amine reported here exhibited remarkable antifungal activity against dermatophytes. Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties. allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties. -(2-furylmethyl)amine reported here exhibited remarkable antifungal activity against dermatophytes. Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties.