INVESTIGADORES
ENRIZ Ricardo Daniel
artículos
Título:
New antifungal peptides. Synthesis, bioassays and initial structure prediction by CD spectroscopy
Autor/es:
MÓNICA S.OLIVELLA; ANA MARÍA RODRIGUEZ; SUSANA A. ZACCHINO; CSABA SOMLAI; BOTOND PENKE; VICTOR FARKAS; ANDRAS PERCZEL; RICARDO DANIEL ENRIZ
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2010 vol. 20 p. 4808 - 4811
ISSN:
0960-894X
Resumen:
The synthesis, in vitro evaluation and conformational study of KKWKMRRNQFWIKIQR-NH2, HFRWRQIKIWFQNRRMKWKK- NH2 and RQPKIWFPNRRKPWKK-NH2 acting as antifungal agents are reported. These peptides displayed a moderate but significant antifungal effect against both pathogenic fungi Candida albicans and Cryptococcus neoformans. The conformational analysis of these peptides was carried out using both theoretical and experimental methods.
