INVESTIGADORES
ENRIZENRIZ] ricardoricardo] danieldaniel]
artículos
Título:
Antifungal and Cytotoxic Activities of some N-substituted Aniline Derivatives bearing a hetaryl fragment
Autor/es:
V.V.KOUZNETSOV, L.Y.VARGAS, M.SORTINO, Y.VASQUEZ, M.P.GUPTA, M.FREILE, R.D.ENRIZENRIZ] S. A.ZACCHINO
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY.
Editorial:
elsevier
Referencias:
Lugar: Amsterdam; Año: 2008 vol. 16 p. 794 - 794
ISSN:
0968-0896
Resumen:
Abstract—Diverse N-substituted anilines bearing hetaryl fragments were easily prepared from corresponding aldimines derived from  ommercially available aromatic aldehydes and anilines. 2-Furyl substituted anilines showed very good antifungal activities against dermatophytes, particularly against Trichophyton rubrum (MIC = 3.12–6.25 lg/mL). In addition, all active compounds, 45–47, 73,  and 74, were tested for cytotoxic activities against breast (MCF-7), lung (H-460), and central nervous system (SF-268) human cancer  cell lines with the NCI-anticancer-drug screen. The activity of amines described in this paper, along with the low toxicity of most of them, shows promise for the future development of non-toxic new antimycotic agents. cell lines with the NCI-anticancer-drug screen. The activity of amines described in this paper, along with the low toxicity of most of hem, shows promise for the future development of non-toxic new antimycotic agents.
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