INVESTIGADORES
ENRIZENRIZ] ricardoricardo] danieldaniel]
artículos
Título:
Penetratin and Derivatives Actino as Antifungal Agents
Autor/es:
M.F.MASMAN, A.M.RODRIGUEZ, M.RAIMONDI, S.A.ZACCHINO, P.G.LUITEN, C.SOMLAI, T. KORTEVELYESI, B.PENKE R.D.ENRIZENRIZ]
Revista:
EUROPEAN JOURNAL OF MEDICAL CHEMISTRY
Editorial:
Elsevier
Referencias:
Lugar: Amsterdam; Año: 2009 vol. 44 p. 212 - 212
ISSN:
0223-5234
Resumen:
Abstract: The synthesis, in vitro evaluation, and conformational study of RQIKIWFQNRRMKWKK-NH2(penetratin) and related derivatives acting as antifungal agents are reported. Penetratin and some of its derivatives displayed antifungal activity against the human opportunistic pathogenic standardized ATCC strains Candida albicans and Cryptococcus neoformans as well as clinical isolates of C. neoformans. Among the compounds tested, penetratin, along with the nonapeptide RKWRRKWKK-NH2 and the tetrapeptide RQKK-NH2 exhibited significant antifungal activities against the Cryptococcus sp. A comprehensive conformational analysis on the peptides reported here using three different approaches, Molecular Mechanics, Simulated Annealing and Molecular Dynamics simulations, was carried out. The experimental and theoretical results allow to identify a topographical template which may provide a guide for the design of new compounds with antifungal characteristics against C. neoformans.
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