INVESTIGADORES
ENRIZENRIZ] ricardoricardo] danieldaniel]
artículos
Título:
In vitro-In vivo Antifungal Evaluation and Structure-Activity Relationsip of Thione Derivatives
Autor/es:
F.A.GIANNINI, L.M.AIMAR, M.V.SORTINO, R.GOMEZ, A.STURNIOLLO, A.JUAREZ, S.ZACCHINO, R. H. DE ROSSI AND R.D.ENRIZENRIZ]
Revista:
IL FARMACO; EDIZIONE PRATICA.
Editorial:
Elsevier
Referencias:
Lugar: Amsterdam; Año: 2004 vol. 59 p. 245 - 245
ISSN:
0014-827X
Resumen:
As part of our project devoted to the search of new antifungal agents, we report here the in vitro–in vivo antifungal evaluations and a structure–activity relationship (SAR) study of 17 thione derivatives.Some compounds of this series exhibited remarkable antifungal activity against a broad spectrum of pathogenic opportunistic fungi. SAR studies provide a useful information for the determination of the minimum structural requirements for producing the biological response.
rds']