INVESTIGADORES
ENRIZENRIZ] ricardoricardo] danieldaniel]
artículos
Título:
Gastric cytoprotective activity of ilicic aldehyde. Structure-activity
Autor/es:
O. J. DONADEL, E. GUERREIRO†, A. O. MARÍA, G. WENDEL, R. D. ENRIZENRIZ], O. S.
Revista:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Editorial:
Elsevier
Referencias:
Lugar: Amsterdam; Año: 2005 vol. 15 p. 3547 - 3547
ISSN:
0960-894X
Resumen:
A series of sesquiterpene compounds possessing both eudesmane and eremophilane skeletons were tested as gastric cytoprotective agents on male Wistar rats. The presence of an a,b-unsaturated aldehyde on the C-7 side chain together with a hydroxyl group at C-4 is the requirement for the observed antiulcerogenic activity. In an attempt to establish new molecular structural requirements for this gastric cytoprotective activity, a structure–activity study was performed.a,b-unsaturated aldehyde on the C-7 side chain together with a hydroxyl group at C-4 is the requirement for the observed antiulcerogenic activity. In an attempt to establish new molecular structural requirements for this gastric cytoprotective activity, a structure–activity study was performed.
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